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Sasidhar, R. L. C.
- Formulation and Evaluation of Lovastatin Solid Dispersions with Pregelatinised Starch as Newer Superdisintegrant
Abstract Views :186 |
PDF Views:89
Authors
Affiliations
1 Department of Biotechnology, Acharya Nagarjuna University, Nagarjuna Nagar, Guntur – 522 510, Andhra Pradesh, IN
2 Department of Pharmaceutics, Chebrolu Hanumaiah Institute of Pharmaceutical Sciences, Guntur - 522 019, Andhra Pradesh, IN
1 Department of Biotechnology, Acharya Nagarjuna University, Nagarjuna Nagar, Guntur – 522 510, Andhra Pradesh, IN
2 Department of Pharmaceutics, Chebrolu Hanumaiah Institute of Pharmaceutical Sciences, Guntur - 522 019, Andhra Pradesh, IN
Source
Journal of Pharmaceutical Research, Vol 11, No 2 (2012), Pagination: 38-43Abstract
Solid dispersions of lovastatin were formulated using pregelatinised starch (PGS) as super disintegrant and were further compressed into tablets by using various diluents such as lactose, dicalcium phosphate (DCP) and microcrystalline cellulose (MCC) to enhance the bioavailability. The solid dispersions were prepared by physical mixing, solvent evaporation and kneading methods. The solid dispersions were found to release the drug faster than the pure drug in dissolution media. The rapid release of poorly soluble lovastatin from solid dispersions was influenced by the proportion of polymer and the method employed for its preparation. Among the three methods employed solvent evaporation and kneading methods were found to be suitable for improving the dissolution rate of lovastatin. The release data was fitted to various kinetic models. The release was found to follow first order kinetics. Some of the dispersions prepared by the solvent evaporation method and kneading method were formulated into tablets with various diluents. The tablet preparations containing different diluents were found to release the drug in the order of DCP>MCC>Lactose. The dissolution rate of tablet formulations prepared with lovastatin solid dispersions (FK1, FS4) were found to release the drug at a faster rate than that of tablets prepared with plain drug.Keywords
Lovastatin, Pregelatinised Starch, Solid Dispersions.- Design and Optimization of Venlafaxine Hydrochloride Controlled Release Tablets Using HPMC K15M
Abstract Views :203 |
PDF Views:88
Authors
Affiliations
1 Chebrolu Hanumaiah Institute of Pharmaceutical Sciences, Chowdavaram, Chandramoulipuram, Guntur – 522 019. Andhra Pradesh, IN
1 Chebrolu Hanumaiah Institute of Pharmaceutical Sciences, Chowdavaram, Chandramoulipuram, Guntur – 522 019. Andhra Pradesh, IN
Source
Journal of Pharmaceutical Research, Vol 11, No 3 (2012), Pagination: 100-104Abstract
Venlafaxine hydrochloride was formulated as oral controlled release matrix tablets using hydrophilic polymer such as hydroxypropyl methyl cellulose (HPMC K15 M) along with electrolytes. In this work a new attempt was made for in situ interactions between drug and electrolytes were devised to control the release of highly water soluble drugs from oral hydrophilic monolithic systems. Electrolytes such as Calcium carbonate, magnesium trisilicate, sodium bicarbonate were used at different concentrations in various formulations, while drug and polymer concentrations were maintained constantly at 1:1 ratios in all the formulations. These electrolytes were used to monitor matrix swelling and gel properties. These findings indicated that the swelling and gel formation in the presence of ionizable species within the hydrophilic matrices provide an attractive alternative for controlled drug delivery from a simple monolithic system. FTIR studies were carried out for some selected formulations, which indicated that there were no interactions between drug and excipients used.Keywords
Venlafaxine Hydrochloride, HPMC K15M, Electrolytes, Controlled Release, Matrix Tablets.- Method Development and Validation for Quantitative Analysis of Aspirin and Simvastatin in Pharmaceuticals by RP- HPLC
Abstract Views :206 |
PDF Views:81
Authors
Affiliations
1 Chebrolu Hanumaiah Institute of Pharmaceutical Sciences, Chandramoulipuram, Chowdavaram, Guntur-522 019 (A.P.), IN
2 Chebrolu Hanumaiah institute of Pharmaceutical sciences, Chandramoulipuram, Chowdavaram, Guntur-522 019 (A.P.), IN
3 Alkem Research Center, Industrial Estate, Opposite Talons Police Station, Navi Mumbai - 410 208, Maharashtra, IN
4 Vignan Institute of Pharmaceutical Technology, Duvvada, Visakhapatnam - 530 046, (A.P.), IN
1 Chebrolu Hanumaiah Institute of Pharmaceutical Sciences, Chandramoulipuram, Chowdavaram, Guntur-522 019 (A.P.), IN
2 Chebrolu Hanumaiah institute of Pharmaceutical sciences, Chandramoulipuram, Chowdavaram, Guntur-522 019 (A.P.), IN
3 Alkem Research Center, Industrial Estate, Opposite Talons Police Station, Navi Mumbai - 410 208, Maharashtra, IN
4 Vignan Institute of Pharmaceutical Technology, Duvvada, Visakhapatnam - 530 046, (A.P.), IN